Blasting is an effective method for efficient rock fragmentation in most open-pit mines, including deep open-pit mines. However, when mining at deeper levels, groundwater increases the cost of drilling and blasting operations due to the use of water-resistant explosives, which reduces the effectiveness of rock fragmentation. To overcome these drawbacks, scientists both domestically and internationally have conducted research on technological solutions to support the loading of water-resistant ANFO explosives in water-filled drill holes, with varying degrees of success and limitations. Building upon previous research, this paper presents a method for loading ANFO explosives in nylon bags on an equivalent model under different conditions. The experimental results on the model allow for the identification of factors that influence the effectiveness of loading water-resistant ANFO explosives in water-filled drill holes. Based on these findings, the proposed charging method can be further improved and serve as a basis for implementing field experiments to apply the proposed technology in open-pit mining operations.