Gout is a common joint disease in Vietnam as well as many countries around the world. In the acute phase of the disease, patients often have to suffer a lot of pain, limit movement, affect sleep, work, and relationships, which greatly affect the emotions of this group of subjects. The assessment of relevant factors is valuable in predicting the likelihood of depression in this group of subjects, thereby making early interventions for high-risk subjects. Objectives: To evaluate some factors related to depressive disorder in patients with chronic gout. Subjects and methods: A cross-sectional descriptive study on 129 chronic gout patients, diagnosed as inpatient treatment at the Department of Musculoskeletal Medicine, Bach Mai Hospital f-rom November 2020 to May 2021, using HAM-D scale and clinical examination. Results: There was a relationship between the rate of depression and factors such as working ability, number of hospital admissions, pain level, sleep disturbance, anxiety disorder with significant results. statistics (p<0.05). No association was found between age, sex, education level, economic status, marital status or duration of illness with depression. Conclusion: Early and appropriate interventions are needed for subjects at high risk of depression.