Can Tho City, the center of the Mekong Delta region, play an important role in the region's socio-economic development. In the historical process, the land of Can Tho has had different names, including the name "Can Tho". This name was officially born in 1876 when the French protectorate established Can Tho county, then changed into Can Tho province. About the name "Can Tho", there are many studies mentioned. However, up to now, there are still different opinions. This article aims to exchange ideas to contribute to the clarification of the origin and meaning of the name "Can Tho" and some related names.