To describe the image features of acute cerebral infarction due to occlusion of the M2 branches of the middle cerebral artery at Bach Mai Hospital. Subjects and methods: A cross-sectional descriptive study on 38 patients diagnosed with acute ischemic stroke due to occlusion of the M2 branches of the middle cerebral artery at the Radiology Center of Bach Mai Hospital from January 2018 to June 2021. Results: The mean age of the patients was 70.5 years old; the female/male ratio was 1.38, and the mean NIHSS score on admission was 14.26. The mean time from onset to performing computed tomography was 192.74 ± 124.92 minutes. The rate of hyperdense artery sign, loss of the gray-white matter interface, sulcal effacement, and loss of insular ribbon sign was 67.6%, 47.1%, 44.1%, and 26.5%, respectively. The mean time from onset to performing magnetic resonance imaging was 100.75 ± 43.07 minutes. 4/4 of patients increased cerebral parenchymal signal intensity on DWI, but only 1/4 increased signal intensity on FLAIR. The left and right M2 branch occlusion rates were 55% and 45%, respectively. Computed tomography angiography and 3D TOF magnetic resonance angiography had 100% accuracy in diagnosing the location of occlusion when compared to digital subtraction angiography. Conclusions: The imaging features appearing on computed tomography and magnetic resonance imaging were consistent with the patient's time of admission. Computed tomography angiography and 3D TOF magnetic resonance angiography had high values in diagnosing the location of occlusion when compared to digital subtraction angiography.