The study aimed to evaluate the effectiveness of intravenous Phenylephrin in preventing hypotension in spinal anesthesia for cesarean section at Duc Giang General Hospital. Method: We did a prospective, self-controlled clinical analysis of 120 women divided into 2 groups, 1 group with prophylactic injection and 1 group without prophylactic 100 µg Phenylephrine, all of which were indicated for anesthesia cesarean section with spinal anesthesia. Lives at Duc Giang General Hospital. The study also analyzed and evaluated cyclic changes at important time points. Result: Through a study of 120 women who indicated an anesthesia cesarean section with spinal anesthesia to prevent hypotension with 100 g of Phenylephrine intravenously, the intraoperative BP level of the group receiving Phenylephrine prophylactic injection was more stable during surgery., the rate of pregnant women who had to be treated to raise BP during surgery in the group injecting Phenylephrine prophylactic before surgery was 20% lower than in the group without intraoperative prophylaxis, accounting for 83.3%. Percentage of relapse without BP reduction in the Phenylephrine prophylaxis group (0%) compared with 16.7% in the non-preventive group. Conclude: This is an effective measure to prevent hypotension, so it should be widely applied widely used in GTTS, especially GTTS for cesarean section. In our country, there needs to be more research on Phenylephrine, to be able to give the optimal dose, the best time to inject the drug. That will enable clinicians to use Phenylephrine effectively and safely.