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Công nghệ sinh học công nghiệp

Võ Thị Bích Thủy; Nguyễn Đăng Tôn; Nông Văn Hải; Nguyễn Đăng Tôn(1); 

Hóa chất môi trường gây rối loạn nội tiết: Những đánh giá rủi ro về độc tính trong mô hình In Vivo và In Vitro

Environmental endocrine disrupting chemicals: toxicological risk assessment by in-vivo and in-vitro models

Tạp chí Công nghệ Sinh học

2012

1

1-13

1811-4989

Hóa chất; Rối loạn nội tiết; DEHP; Flutamide; Hoạt tính estrogen; Hoạt tính androgen

Over the last 50-60 years, a growing body of evidence suggests that numerous chemicals, both natural and man-made, may interfere with the endocrine system and produce adverse effects in human and animals. Scientists often refer to these chemicals as "endocrine disruptors". These chemicals, e.g. 2,2-bis-(4hydroxyphenyl)propane (BPA), 4-tert-octylphenol (OP), 4-nonylphenol (NP), di-(2-ethylhexyl) phthalate (DEHP), Flutamide, Parabens etc. are found in many of everyday used products, including some plastic bottles, metal food cans, detergents, flame retardants, food ingredients, toys, cosmetic consumer products, pharmaceutical preparations and pesticides. Although, human may expose to endocrine disruptors through food and beverages they consume, medicine they take, and cosmetics they use, limited scientific infonnation is available on the potential adverse human health issues. Further investigation is needed to elucidate in greater detail the adverse effects of environmental endocrine disrupting chemicals on the epidemiology, immunology, pathology and molecular biology in order to provide a robust and reliable assessment to consumers prior to the direction in the use of several products in their life.

TTKHCNQG, CVv262

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