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 Lượt truy cập :  14,927,694

81.09.03

Kỹ thuật vật liệu và luyện kim

Nguyễn Thúy Chinh; Nguyễn Thị Thu Trang; Trần Thị Mai; Thái Hoàng; Nguyễn Thúy Chinh(1)

Chế tạo, đặc trưng và hình thái cấu trúc của màng chitosan mang Nifedipine

Preparation, characterization and morphology of chitosan film containing nifedipine

Khoa học và Công nghệ

2015

5

637-645

0866-708X

Màng chitosan; Nifedipin; Chế tạo; Cấu trúc; Tính chất nhiệt

This paper presents some characters and morphology of films based on chitosan (CS) and nifedipine (NIF) with various NIF content prepared by solution method. The characteristic peaks of some groups in CS and NIF in Fourier transform infrared spectroscopy (FTIR) spectra of the CS/NIF films shift slightly in comparison with that in the FTIR spectra of CS and NIF. This proved that CS and NIF were interacted with each other. NIF dispersed in the CS matrix with the relatively small size from 200 nm to 2 um. Thermal analysis results showed that the CS/NIF films have less thermostable than the CS. The calibration equations of NIF were set up from data of UV-Vis spectra and regression coefficients obtained higher than 0.996. In vitro release study of CS/NIF films indicated drug release rate was almost higher in pH 7.4 solution than that in pH 6.8 solution for the samples containing 10, 30 and 50 wt percent NIF.

TTKHCNQG, CVv 5