This study aimed to understand the bacterial and parasitic pathogens that cause diseases in Asian swamp eels (Monopterus albus) from the fingerling to grow-out stag stage to the commercial farming stage. The study was carried out from 12/2021 to 05/2022. Results showed that there were 6 genera of parasites including Camalanus, Carassotrema, Caryophyllaeus, Clonorchis, Pallisentis, Proteocephalus, and endoparasite in intestines. Fry stage of the eel was not infected with parasites. The grow-out stage, the prevalence of Camalanus was highest (38.9%), and the lowest was Caryophyllaeus (23.3%). Bacteria were commonly isolated from kidney samples of the eels. Clinical signs were found such as bloating, red and swelling anus, skin with white patches, hemorrhage, ulceration, and dark red and loose liver, kidney and spleen. The use of API 20E kit identified bacterial species, Aeromonas hydrophila. The results of antimicrobial sensitivity tests showed that A. hydrophila isolates were highly susceptibleto cefotaxime and florfenicol