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76.33

Dịch tễ học

Trần Thị Thanh Huế; Lê Văn Đạt; Đoàn Thị Mai Hương; Nguyễn Thị Minh Hằng; Phạm Văn Cường; Nguyễn Văn Hùng; Nguyễn Thị Minh Hằng(1)Đoàn Thị Mai Hương(2)Phạm Văn Cường(3)

Đánh giá độc tính cấp và bán trường diễn của amodiaquin hydroclorid

Experimental estimation of acute and subacute toxicity of amodiaquine hydrocloride

Dược học

2012

434

25-31

0866-7225

Y học; Dịch tễ học; Bệnh sốt rét; Amodiaquin hydroclorid; Độc tính cấp; Bán trường diễn

As amodiaquine well serves as one of main drugs in the new global strategy of combination therapies for malaria control, following our previous study on synthesis of amodiaquine from 4,7-dichloroquinoline, in this study amodiaquine hydrocloride was experimentally evaluated for acute and subchronic oral toxicity in mice and rabbits. The LD50 of amodiaquine in mice was (689.3 + or - 30.9) mg/kg body weight in single dose administration. In 28 days' subchronic study in rabbits, amodiaquine were administrated at doses of 40mg and 60 mg/kg/day for 28 days on end. After such 28 days' course, blood and tissue samples were taken for hematological, biochemical and histopathological evaluation. All the hematological, biochemical parameters and histophathological signs showed non-significant difference between the treament and control groups; but mild liver congestion, mild hepatis, and mild nephritis were seen in a few individuals.

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