To describe the results of prenatal diagnosis and postpartum status of fetuses diagnosed with agenesis of corpus callosum (ACC) at the Prenatal Diagnosis Center of the National Hospital of Obstetrics and Gynecology.Materials: 181 pregnant women who visisted the Prenatal Diagnosis Center of the National Hospital of Obstetrics and Gynecology were diagnosed with agenesis of corpus callosum.Methods:Retrospective descriptive study. Results:Complete ACC accounted for 92,3%, isolated ACC accounted for 64,6%, non-isolated ACC accounted for 35,4%. Features on ultrasound: ventricular dilatation 81,8%, tear drop sign 83,4%, sign of two frontal horn running parallel 95,6%, absent of the septum pellucidum 97,2%, direct demonstration of ACC 66,3%. The rate of ventricular dilatation at the time of dignosis increased gradually with gestration age: from 22 weeks or less 61,5%, from 23-28 weeks 77,6%, from 29 weeks or more 92,8%, The group of isolated ACC was diagnosed later, the rate of termination of pregnancy (43,6%) was lower than that of the group with non-isolated ACC (78,1%). The most comon lesion associated with ACC was central nervous system abnormalities (cerebral cyst at the position of the septum pellucidum, cortical abnormalities and Dandy Walker malformations...). 16 cases had aminocentesis: 15 cases (93,8%) had normal karyotype, 1 case (6,2%) 46 XY, 1qh+. In 52 cases of post partum follow up: 63,5% had normal development, 13,5% psychomotor retardation compared to children of the same age, speed delay 5,7%, epilepsy 3,8%, postpartum death 13,5%.Conclusion:ACC can be diagnosed by second and third-trimester ultrasound. Diagnoses of combined leisons play an important role in prognosis.
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