Nghe An is evaluated as a land with extremely important geographical - political position; having young and creative human resources; great potential for land, mainly basalt red soil, large forestry land area; many beautiful national parks and nature reserves, high biodiversity, and medicinal herbs..., which are extremely suitable for the development of large-scale cultivation industry. In order to take fully advantages f-rom the strengths of the province, the local government is implementing a restructuring plan in the direction of increasing added value, developing the cultivation industry with applying high technology, and at the same time ensuring sustainability in response to climate change. The application of advanced technology in each stage or in the whole production chain will bring high added value to products as well as help promote the construction of hi-tech cultivation zones concentrated in Nghe An. The article analyzes the advantages and challenges of developing the hi-tech cultivation industry in Nghe An, thereby proposing some suitable solutions for this activity of the province.