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Phí Thị Đào, Vũ Văn Nam, Nguyễn Thùy Linh, Trần Văn Hiệu, Đoàn Thị Mai Hương, Phạm Văn Cường

TỔNG HỢP MỘT SỐ CHẤT LỎNG ION VÀ ỨNG DỤNG TRONG PHẢN ỨNG TỔNG HỢP CHẤT TRUNG GIAN CỦA DẪN XUẤT SCHWEINFURTHIN G

SYNTHESIS OF IONIC LIQUIDS AND THEIR APPLICATION IN THE SYNTHESIS OF INTERMEDIATE COMPOUNDS OF SCHWEINFURTHIN G DERIVATIVESSYNTHESIS OF IONIC LIQUIDS AND THEIR APPLICATION IN THE SYNTHESIS OF INTERMEDIATE COMPOUNDS OF SCHWEINFURTHIN G DERIVATIVES

Tạp chí Phân tích Hóa, Lý và Sinh học

2024

2

07

Ionic liquids (ILs) have gained much attention as green reaction solvents for organic synthesis. In this paper, four ionic liquids [(1R,2S)-N-octyl-N,N-dimethylephedrinium hexafluorophosphate, (1R,2S)-N-octyl N,N-dimethylephedrinium trifluoromethanesulfonate, 1-methyl-3-n-octylimidazolium trifluoromethanesulfonate and 1-butyl-3-methylimidazolium hexafluorophosphate] were prepared by using microwave irradiation with yields ranging from 84% to 86%. Furthermore, these ionic liquids were applied to prepare intermediate derivatives in the synthesis process of schweinfurthin G derivatives. The ionic liquid, (1R,2S)-N-octyl-N,N-dimethylephedrinium trifluoromethanesulfonate was more effective in the shorten reaction time, comparing with remaining ionic liquids. The structures of ionic liquids and the intermediate derivatives were determined by analyses of MS and NMR data.

Ionic liquids (ILs) have gained much attention as green reaction solvents for organic synthesis. In this paper, four ionic liquids [(1R,2S)-N-octyl-N,N-dimethylephedrinium hexafluorophosphate, (1R,2S)-N-octyl N,N-dimethylephedrinium trifluoromethanesulfonate, 1-methyl-3-n-octylimidazolium trifluoromethanesulfonate and 1-butyl-3-methylimidazolium hexafluorophosphate] were prepared by using microwave irradiation with yields ranging from 84% to 86%. Furthermore, these ionic liquids were applied to prepare intermediate derivatives in the synthesis process of schweinfurthin G derivatives. The ionic liquid, (1R,2S)-N-octyl-N,N-dimethylephedrinium trifluoromethanesulfonate was more effective in the shorten reaction time, comparing with remaining ionic liquids. The structures of ionic liquids and the intermediate derivatives were determined by analyses of MS and NMR data.

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