Objective: Evaluation the efficacy of topical diprosalic oitment on treatment of lichen planus. Material and method: 32 patients with lichen planus were treated by topical diprosalic ointment in twice a day. The results were evaluated basing on the itching, appearing new lesions and the reducing thickness of lesion measured by ultrasound machine ACUSON after 2.4 and 8 weeks treatment. Results: After 8 weeks of the treatment, all patients has no itching, two patients still had new lesions. The thickness of the lesions before treatment was 2.8 +/- 0.8 mm, 2 times thicker than that of normal skin nearby. After 8 weeks of the treatment, the thickness of the lesion was 1.52 +/- 0.4 mm, comparative with the normal skin. In general, the complete remission was achieved in 78.1 percent of the patients, moderate remission in 12.5 percent; 6.3 percent in partial remission and poor in 3.1 percent of the patients. There were 4 patients (12.5 percent) suffered from cutaneous atrophy, 12.5 percent with hyper-pigmentation, 9.4 percent with skin irritant and 6.3 percent with telangiectasia. Conclusions: Topical diprosalic oitment achieved good result after 8 weeks of the treatment. Some side effects such as cutaneous atrophy, hyper-pigmentation, telangiectansia... could be noted during the treatment.
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